Activation of Nkx2.5 transcriptional program is required for adult myocardial repair

Autor: Carmen de Sena-Tomás, Angelika G. Aleman, Caitlin Ford, Akriti Varshney, Di Yao, Jamie K. Harrington, Leonor Saúde, Mirana Ramialison, Kimara L. Targoff
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30468-4
Popis: Cardiac developmental genes have been associated with regenerative potential. Here the authors identify a Nkx2.5-dependent gene regulatory network operating through ect2, psmb3, and psmd7 to orchestrate cell cycle re-entry, proteolysis, and mitochondrial metabolism during myocardial repair.
Databáze: Directory of Open Access Journals