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ObjectiveTo evaluate postoperative cerebral perfusion changes and their influencing factors in carotid endarterectomy (CEA) patients by integrating multimodal monitoring methods, including cerebral regional oxygen saturation (rSO2), carotid ultrasound (CU), computed tomographic angiography (CTA), and computed tomographic perfusion imaging (CTP), with computational fluid dynamics (CFD) assessment.MethodsWe conducted a cohort study on patients with internal carotid artery (ICA) stenosis undergoing CEA at our institution. Pre- and postoperative assessments included CU, CTA, CTP, and rSO2 monitoring. Hemodynamic parameters recorded were mean flow velocity (MFV), peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI), rSO2, and cerebral blood flow (CBF). CFD quantified the total pressure (TP), wall shear stress (WSS), wall shear stress ratio (WSSR), and translesional pressure ratio (PR) of the ICA. Pearson correlation was used to analyze factors influencing cerebral perfusion changes. Multivariate logistic regression identified risk factors for cerebral hyperperfusion (CH). The predictive value of multimodal and single-modality monitoring for CH was evaluated using ROC curve analysis.ResultsFifty-six patients were included, with nine developing postoperative CH. CU showed significant reductions in MFV, PSV, EDV, and RI of the ICA (p |
