Chemical constituents of aerial parts of Thymus gobicus and their cholinesterase inhibitory activities

Autor: Odonbayar B, T Murata, N Matsumoto, Batkhuu J, K Sasaki
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Mongolian Journal of Chemistry, Vol 17, Iss 43, Pp 14-17 (2017)
Druh dokumentu: article
ISSN: 2226-6739
2414-0082
DOI: 10.5564/mjc.v17i43.740
Popis: From an acetone-water (3:2) extract of aerial parts of Thymus gobicus Czern. (31.1 g), compounds 1-8 were obtained using high-performance liquid chromatography. Based on spectroscopic data, the isolated compounds were identified as rosmarinic acid (1), monardic acid A (2), nepetoidin B (3), aromadendrin (4), apigenin (5), chrysoriol (6), apigenin 7-O-β-D-glucuronopyranoside (7), and apigenin 7-O-β-D-glucuronopyranoside methyl ester (8). Compound 2 was a (7R,8R)-diastereomer of lithospermic acid (2a). Although it was reported that the anti-allergic activity of lithospermic acid was higher than that of 2, the acetylcholine inhibitory activity of 2 was higher than that of lithospermic acid.
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