IKKε isoform switching governs the immune response against EV71 infection
| Autor: | Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen, Sui-Yuan Chang, Yao-Ting Huang, Bing-Ching Ho, Sung-Liang Yu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2399-3642 10564527 |
| DOI: | 10.1038/s42003-021-02187-x |
| Popis: | Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a potential strategy for boosting host’s antiviral defense. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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