Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

Autor: Szymon P. Kordon, Przemysław Dutka, Justyna M. Adamska, Sumit J. Bandekar, Katherine Leon, Satchal K. Erramilli, Brock Adams, Jingxian Li, Anthony A. Kossiakoff, Demet Araç
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36312-7
Popis: Adhesion GPCRs have numerous functions, ligands and isoforms. Here, Kordon et al. report synthetic antibodies that both modulate aGPCR signaling in an isoform-specific manner, and break receptor interactions in a ligand-specific manner
Databáze: Directory of Open Access Journals
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