Longer duration of high-dose corticosteroids provides benefit for hospitalized COVID-19 patients with high oxygen requirement
| Autor: | Junping Fan, Huaiya Xie, Yaqi Wang, Siqi Pan, Tingyu Wang, Chuan Shi, Xinjie Hui, Huan Hou, Xiaoxing Gao, Wangji Zhou, Xiangning Liu, Yunxin Liu, Jinglan Wang, Xinlun Tian |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Heliyon, Vol 10, Iss 22, Pp e40059- (2024) |
| Druh dokumentu: | article |
| ISSN: | 2405-8440 18463983 |
| DOI: | 10.1016/j.heliyon.2024.e40059 |
| Popis: | The optimal corticosteroids dose in patients with coronavirus disease 2019 (COVID-19) requiring high oxygen remains unknown. In this retrospective study of patients with COVID-19 requiring high oxygen and receiving corticosteroids, the efficacy, safety, and duration of high-dose treatment were evaluated. The primary outcome was all-cause mortality during follow-up. Safety outcomes included infection, gastrointestinal bleeding, and venous thromboembolic events. 210 patients were included, with 126 in Group A (corticosteroids at a equivalent dose 5 days). The all-cause mortality risk was lower in Group C but higher in Group B than in Group A. Safety outcomes did not differ significantly, except for Group C, which had the highest venous thromboembolism rate. Our results suggest that high-dose corticosteroids for a longer course decrease mortality with comparable safety outcome. |
| Databáze: | Directory of Open Access Journals |
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