Intricate crosstalk between MYC and non‐coding RNAs regulates hallmarks of cancer

Autor: Lotteke J. Y. M. Swier, Agnieszka Dzikiewicz‐Krawczyk, Melanie Winkle, Anke van denBerg, Joost Kluiver
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular Oncology, Vol 13, Iss 1, Pp 26-45 (2019)
Druh dokumentu: article
ISSN: 1878-0261
1574-7891
DOI: 10.1002/1878-0261.12409
Popis: Myelocytomatosis viral oncogene homolog (MYC) plays an important role in the regulation of many cellular processes, and its expression is tightly regulated at the level of transcription, translation, protein stability, and activity. Despite this tight regulation, MYC is overexpressed in many cancers and contributes to multiple hallmarks of cancer. In recent years, it has become clear that noncoding RNAs add a crucial additional layer to the regulation of MYC and its downstream effects. So far, twenty‐five microRNAs and eighteen long noncoding RNAs that regulate MYC have been identified. Thirty‐three miRNAs and nineteen lncRNAs are downstream effectors of MYC that contribute to the broad oncogenic role of MYC, including its effects on diverse hallmarks of cancer. In this review, we give an overview of this extensive, multilayered noncoding RNA network that exists around MYC. Current data clearly show explicit roles of crosstalk between MYC and ncRNAs to allow tumorigenesis.
Databáze: Directory of Open Access Journals
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