Second phase Chiba study of mother and child health (C-MACH): Japanese birth cohort study with multiomics analyses
| Autor: | Chisato Mori, Masahiro Watanabe, Akifumi Eguchi, Akira Hata, Masaya Koshizaka, Kenichi Sakurai, Midori Yamamoto, Hideoki Fukuoka, Naoki Shimojo, Masamichi Hanazato, Norimichi Suzuki, Akiko Kawanami, Kohki Takaguchi, Rieko Takatani, Aya Hisada, Yuki Konno, Kayo Tsumura, Keiichi Shimatani |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | BMJ Open, Vol 14, Iss 12 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2024-0856 2044-6055 |
| DOI: | 10.1136/bmjopen-2024-085682 |
| Popis: | Purpose Epidemiological studies have reported that environmental factors from fetal period to early childhood can influence the risk of non-communicable diseases in adulthood. This concept has been termed the developmental origins of health and disease (DOHaD). The Chiba study of Mother and Child Health (C-MACH) is a DOHaD concept-based birth cohort study which started in 2014. This study aims to investigate the effects of genetic and environmental factors, particularly fetal and postnatal living environment, on children’s health. We also aim to identify candidate biomarkers for their health status. Moreover, the second phase study of C-MACH which was initiated in 2021 aimed at expanding the sample size, especially for gut microbiota and epigenomic analysis; it also aimed at clarifying the impact of the coronavirus disease 2019 (COVID-19) pandemic on children’s health.Participants This study consists of four hospital-based cohorts. Women who were |
| Databáze: | Directory of Open Access Journals |
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