Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia
| Autor: | James M. Otto, James O.M. Plumb, Eleri Clissold, Shriya B. Kumar, Denis J. Wakeham, Walter Schmidt, Michael P.W. Grocott, Toby Richards, Hugh E. Montgomery |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 102, Iss 9 (2017) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.2017.169680 |
| Popis: | In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l−1 in non-pregnant females and < 130 g.l−1 in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, measuring hemoglobin concentration, total hemoglobin mass (optimized carbon monoxide rebreathing method) and thereby calculating plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r=0.687–0.871, P |
| Databáze: | Directory of Open Access Journals |
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