Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT

Autor: Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon, Heather Hook, Gopal Karemore, Michael U. J. Oliphant, Weiwei Lin, Qian Liu, Sadhna Phanse, Carl White, Dzmitry Padhorny, Sergei Kotelnikov, Christopher S. Chen, Pingzhao Hu, Gerald V. Denis, Dima Kozakov, Brian Raught, Trevor Siggers, Stefan Wuchty, Senthil K. Muthuswamy, Andrew Emili
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36122-x
Popis: Epithelial-to-mesenchymal transition (EMT) is a complex process regulated at multiple molecular levels. Here, the authors implement an analytic framework - PAMAF - to integrate data from twelve distinct omics modalities, which they use to understand the molecular changes and regulation during EMT in vitro.
Databáze: Directory of Open Access Journals