Association of left ventricular structural remodeling types with fibronectin deficiency in patients with multivessel coronary artery disease

Autor: A. R. Mingalimova, N. G. Gumanova, N. M. Bikbova, O. N. Dzhioeva, M. S. Pokrovskaya, I. A. Efimova, Z. Z. Serebryanskaya, N. L. Bogdanova, A. L. Borisova, O. M. Drapkina
Jazyk: ruština
Rok vydání: 2023
Předmět:
Zdroj: Российский кардиологический журнал, Vol 28, Iss 12 (2023)
Druh dokumentu: article
ISSN: 1560-4071
2618-7620
DOI: 10.15829/1560-4071-2023-5532
Popis: Aim. To evaluate the serum fibronectin level in patients with multivessel coronary artery disease, and to identify the relationship of fibronectin level with atrial fibrillation (AF) developed in the hospital after coronary artery bypass grafting (CABG) and types of left ventricular (LV) structural remodeling.Material and methods. This prospective observational study of 80 patients after elective CABG at the Cardiac Surgery Department № 1 of the N. V. Sklifosovsky Research Institute for Emergency Medicine from October 2020 to May 2022. The groups were divided depending on the development of AF after CABG surgery (19 patients with AF developed in the hospital after CABG (up to 10 days), 61 patients — control group). All patients underwent a general clinical examination and transthoracic echocardiography, with estimation of left ventricular remodeling type. Serum fibronectin level was determined by enzyme immunoassay using the Fibronectin agent (Technozym, Austria).Results. The median fibronectin values in the group with AF was 110,10 [86,86; 134,00] mcg/ml versus 120,90 [92,01; 161,50] µg/ml of the comparison group (p=0,19). The following LV patterns were observed: normal LV geometry (NLVG) — in 1 patient (5,26%), concentric LV remodeling (CLVR) — in 3 patients (15,79%), concentric LV hypertrophy (CLVH) — in 10 patients (52,63%), eccentric LV hypertrophy (ELVH) — in 5 patients (26,32%). In the group without AF, 25 patients (40,98%) were diagnosed with NLVG, 26 patients (42,62%) — CLVR, 6,56% (n=4) — CLVR, while ELVH was diagnosed in 6 patients (9,84%). Differences in geometry types between groups were significant (p
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