Turcot Syndrome: A Synchronous Clinical Presentation of Glioblastoma Multiforme and Adenocarcinoma of the Colon

Autor:	Sabiq Dipro, Faisal Al-Otaibi, Adel Alzahrani, Anwar Ulhaq, Essam Al Shail
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Case Reports in Oncological Medicine, Vol 2012 (2012)
Druh dokumentu:	article
ISSN:	2090-6706 2090-6714
DOI:	10.1155/2012/720273
Popis:	Turcot syndrome (TS) is a rare hereditary disorder clinically characterized by the occurrence of primary tumors of the colon and the central nervous system (CNS). Here we present the case of an 11-year-old boy with a synchronous clinical presentation of both glioblastoma multiforme (GBM) and colonic adenocarcinoma. A molecular genetic study revealed microsatellite instability in the DNA mismatch repair (MMR) gene. This patient ultimately survived for 13 months after clinical presentation. Based on this case study, the synchronous presentation of glioblastoma multiforme and adenocarcinoma of the colon might suggest a shorter survival rate for patients with Turcot syndrome. A literature review complements this paper.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f06f3f758a7140dd9602dd35987e368d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF