Synthesis and Antimalarial Evaluation of Cyclic β-Amino Acid-Containing Dipeptides

Autor: M. P. Kaushik, A. K. Srivastava, D. Thavaselvam, Manisha Sathe
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Molecules, Vol 13, Iss 2, Pp 432-443 (2008)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules13020432
Popis: This paper describes an efficient synthesis and the antiparasitic evaluation ofcyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial propertiesof all these dipeptides have been evaluated in vitro against Plasmodium falciparum and invivo against Plasmodium berghai. Compounds 4.4 and 4.5 have been found to be veryeffective in this respect, with IC50 values of 3.87 and 3.64 μg/mL in the in vitro test, while4.5 has also been found to be active in the in vivo evaluation.
Databáze: Directory of Open Access Journals
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