| Autor: |
Anthony Catchpole, Donogh Maguire, John M. Wadsworth, Donald C. McMillan, Owen Sheerins, Mark Blyth, Andrew Shaw, Bryn Jones, Colin Drury, Dinesh Talwar |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Clinical Nutrition Open Science, Vol 53, Iss , Pp 25-34 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-2685 |
| DOI: |
10.1016/j.nutos.2023.12.001 |
| Popis: |
Summary: Background: Selenium is an essential trace element and its deficiency can lead to dysfunction in multiple areas. Selenium status is commonly assessed by its measurement in plasma but this may be an unreliable marker in patients with systemic inflammatory response (SIR). Erythrocyte selenium is an alternative marker that appears not to be perturbed by the SIR. Objectives: Examine the effect of the magnitude of acute and chronic SIR on plasma and erythrocyte selenium concentrations. Methods: Acute inflammation: Blood samples were collected in patients (n=16) undergoing elective knee arthroplasty pre-operatively and post-operatively (24 and 48 hours and 3 months). Chronic inflammation: Blood samples were collected in patients receiving nutritional support who presented for routine micronutrient screening (n = 3798). CRP was used as a marker of inflammation. Plasma and erythrocyte selenium concentrations were divided into 3 inflammatory groups: minor, moderate and major defined as CRP80 mg/L. Results: Plasma selenium concentrations reduced with increasing CRP concentrations from minor to moderate to major inflammation (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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