IgM-Related Immunoglobulin Light Chain (AL) Amyloidosis

Autor: Shayna Sarosiek, Andrew R. Branagan, Steven P. Treon, Jorge J. Castillo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Hemato, Vol 3, Iss 4, Pp 731-741 (2022)
Druh dokumentu: article
ISSN: 2673-6357
DOI: 10.3390/hemato3040049
Popis: Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic disorder characterized by an IgM paraprotein. The clinical presentation of WM varies and can include common manifestations such as anemia and hyperviscosity, in addition to less common features such as cryoglobulinemia, IgM-related neuropathy, and immunoglobulin light chain (AL) amyloidosis. Amyloidosis is a protein-folding disorder in which vital organ damage occurs due to the accumulation of misfolded protein aggregates. The most common type of amyloidosis in patients with an IgM paraprotein is AL amyloidosis, although other types of amyloidosis may occur. IgM-related amyloidosis has distinct clinical features when compared with other subtypes of AL amyloidosis. This review highlights the diagnostic criteria of IgM-related AL amyloidosis, as well as the clinical characteristics and treatment options for this disorder.
Databáze: Directory of Open Access Journals
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