New polychlorinated bibenzyls from Rhododendron minutiflorum
| Autor: | Yang-Li Zhu, Li Deng, Yu Tang, Xian-Zhe Fan, Yang Han, Mei Pan, Li-Jun Zhang, Hai-Bing Liao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2192-2195 2192-2209 |
| DOI: | 10.1007/s13659-022-00364-x |
| Popis: | Abstract Five new polychlorinated bibenzyls (1–5) along with 3 known compounds (6–8) were isolated from the stems and leaves of Rhododendron minutiflorum. The chemical structures of all the isolates were determined by spectroscopic methods, and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses. Compounds 1–5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures. Biologically, compounds 2, 5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid (Diaphorina citri) with LD50 values 27.15, 17.02 and 16.20 mg/L, respectively. These values were comparable to the positive control matrine (LD50 = 11.86 mg/L), which were calculated using observations on day 6. Meanwhile, compound 4 had α-glucosidase inhibitory activity with IC50 value of 17.87 ± 0.74 μM. Graphical Abstract |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink