Applying a Tripodal Hexaurea Receptor for Binding to an Antitumor Drug, Combretastatin-A4 Phosphate

Autor:	Yu Kong, Rong Zhang, Boyang Li, Wei Zhao, Ji Wang, Xiao-Wen Sun, Huihui Lv, Rui Liu, Juan Tang, Biao Wu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	anion coordination tripodal hexaurea receptors transmembrane transport phosphate drug Technology Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Zdroj:	Materials, Vol 17, Iss 11, p 2570 (2024)
Druh dokumentu:	article
ISSN:	1996-1944
DOI:	10.3390/ma17112570
Popis:	Phosphates play a crucial role in drug design, but their negative charge and high polarity make the transmembrane transport of phosphate species challenging. This leads to poor bioavailability of phosphate drugs. Combretastatin-A4 phosphate (CA4P) is such an anticancer monoester phosphate compound, but its absorption and clinical applicability are greatly limited. Therefore, developing carrier systems to effectively deliver phosphate drugs like CA4P is essential. Anion receptors have been found to facilitate the transmembrane transport of anions through hydrogen bonding. In this study, we developed a tripodal hexaurea anion receptor (L1) capable of binding anionic CA4P through hydrogen bonding, with a binding constant larger than 104 M−1 in a DMSO/water mixed solvent. L1 demonstrated superior binding ability compared to other common anions, and exhibited negligible cell cytotoxicity, making it a promising candidate for future use as a carrier for drug delivery.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f0352dd07af74f0b88c2d443b8de9d0f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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