Bacterial Porins and Their Procoagulant Role: Implication in the Pathophysiology of Several Thrombotic Complications during Sepsis

Autor: Carmine Siniscalchi, Alessandro Perrella, Ugo Trama, Francesca Futura Bernardi, Egidio Imbalzano, Giuseppe Camporese, Vincenzo Russo, Olga Scudiero, Tiziana Meschi, Pierpaolo Di Micco
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Toxins, Vol 16, Iss 8, p 368 (2024)
Druh dokumentu: article
ISSN: 2072-6651
DOI: 10.3390/toxins16080368
Popis: The association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ. In this review, we have summarized the role that bacterial products such as porins and toxins can have in the induction of the prothrombotic state during sepsis and the interaction that they can have with each other. Furthermore, the above-mentioned mechanisms might be involved in the pattern of the clinical presentation of thrombotic events during bacterial sepsis, which would secondarily explain the association between sepsis and venous thromboembolism, the association between sepsis and disseminated intravascular coagulation, and the association between sepsis and microangiopathic venous thromboembolism.
Databáze: Directory of Open Access Journals
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