Virus-associated chronic endometritis: treatment options

Autor: Natalia I. Tapilskaya, Gulrukhsor Kh. Tolibova, Tatiana G. Tral, Alevtina M. Savicheva, Ruslan I. Glushakov, Gavkar A. Sadikova, Olga V. Budilovskaya, Anna A. Krysanova, Alexander M. Gzgzyan, Olesya N. Bespalova
Jazyk: ruština
Rok vydání: 2022
Předmět:
Zdroj: Гинекология, Vol 24, Iss 5, Pp 348-354 (2022)
Druh dokumentu: article
ISSN: 2079-5696
2079-5831
20795696
DOI: 10.26442/20795696.2022.5.201693
Popis: Aim. To evaluate the effectiveness of Alloferon (Allokin-alfa) in the complex treatment of virus-associated chronic endometritis (CE) in patients with infertility, papillomavirus infection (PVI) persisting in the uterine cavity, and recurrent herpes-virus infection localized in the genital area. Materials and methods. A prospective (n=33) open randomized (2:1) study was conducted to assess the efficacy of Alloferon (Allokin-alfa) in the complex treatment of CE in patients with infertility, PVI, and recurrent herpes-virus infection, aged 25 to 37 years (median age 31 [29; 32.5] years). All patients received valacyclovir therapy at 500 mg once daily for 30 days from the day of randomization. Patients in the main group (n=21) simultaneously with the start of antiviral therapy received Allokin-alfa as 9 subcutaneous injections once every two days (one injection every other day). The uterine cavity microbiota of the patients was assessed 3 months after treatment, and histological and immunohistochemical studies of endometrial biopsy specimens were performed. Results. The microbiological data analysis showed HPV elimination in 71.4% vs 16.7% of patients in the alloferon and control groups, respectively (2 7.102, p=0.008). Also, in the main group, a significant decrease in the severity of CE (2 27.586, p0.001) and p16ink4a protein expression levels (2 6.17, p=0.013) were observed. Conclusion. In the treatment of virus-associated CE, the addition of alloferon to virus-suppressive therapy leads to higher rates of HPV elimination from the uterine cavity and significantly reduces the severity of CE.
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