The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity

Autor:	Lang Rao, Youbao Sha, N. Tony Eissa
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	autophagy proteasome ubiquitin chip tfeb stub1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2017.1372867
Popis:	TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin proteasome pathway. Thus, the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f018ee2c94df495c8d2cfd050a9adbdc Zobrazit plný text záznamu View record in DOAJ