| Autor: |
Chin-Chuen Lin, Chien-Te Lee, Ya-Ting Lo, Tiao-Lai Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Biomedical Journal, Vol 39, Iss 4, Pp 272-276 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2319-4170 |
| DOI: |
10.1016/j.bj.2016.08.001 |
| Popis: |
Background: Brain-derived neurotrophic factor (BDNF) protein or mRNA levels may be involved in the pathophysiology of bipolar disorder. However, the results were inconsistent. We aimed to simultaneously investigate the relationship of BDNF protein and mRNA levels in peripheral blood of patients with bipolar mania. Methods: Patients with bipolar mania (n = 30) and healthy controls (n = 30) were recruited during our one-year study. Psychiatric diagnoses were made according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria. The scores of the Young Mania Rating Scale (YMRS) of patients with bipolar mania were greater than 26. All participants had peripheral blood drawn to analyze the serum BDNF protein and mRNA levels. Results: Using t-test, patients with bipolar mania had a lower BDNF protein and mRNA levels than did the healthy controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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