Neurocognitive outcomes following fetal exposure to chemotherapy for gestational breast cancer: A Canadian multi-center cohort study

Autor: Cynthia Maxwell, Sepand Alavifard, Ellen Warner, Maru Barrera, Christine Brezden-Masley, Nicolas Colapinto, Shima Kassirian, Yolanda Madarnas, Sridhar Srikala, Richard Tozer, Joanne Yu, Irena Nulman
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Breast, Vol 58, Iss , Pp 34-41 (2021)
Druh dokumentu: article
ISSN: 1532-3080
01273329
DOI: 10.1016/j.breast.2021.04.005
Popis: Background: Limited knowledge exists on outcomes of children exposed prenatally to chemotherapy for breast cancer (BC). The purpose of this study was to compare long-term neurocognitive, behavioral, developmental, growth, and health outcomes of children exposed in-utero to chemotherapy for BC. Methods: This is a multi-center matched cross-sectional cohort study involving seven cancer centers across the region of Southern Ontario (Canada), and the Hospital for Sick Children (Toronto, Ontario). Using standardized psychological and behavioral tests, we compared cognitive and behavioral outcomes in children exposed to chemotherapy during pregnancy for BC to age-matched pairs exposed to known non-teratogens. Results: We recruited 17 parent-child pairs and their matched controls. There were more preterm deliveries in the chemotherapy-exposed group compared to controls (p
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