Breast neuroendocrine tumor arising in the axilla of a man: a case report

Autor: Kosei Kimura, Shigeru Kawabata, Hiroyo Oku, Ayana Ikari, Tomo Tominaga, Saki Takai, Junna Sakane, Michiaki Tanaka, Chinatsu Aoki, Monika Ota, Erika Minami, Yoshinobu Hirose, Sang-Woong Lee, Mitsuhiko Iwamoto
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Medical Case Reports, Vol 16, Iss 1, Pp 1-5 (2022)
Druh dokumentu: article
ISSN: 1752-1947
DOI: 10.1186/s13256-022-03683-2
Popis: Abstract Background Accessory breast carcinomas of the axilla of males are rare, and primary breast neuroendocrine tumors (BNETs) are rare as well. We present a case of a BNET arising in the axilla of a man. Case presentation A 64-year-old Japanese man presented with a hard 15-mm mass in the axilla and axillary lymph node swelling. Histopathological examination of the incisional biopsy specimen revealed a neuroendocrine carcinoma. Therefore, wide radical excision of the axillary tumor and axillary lymph node dissection were performed. Hematoxylin and eosin staining showed that the solid tumor was mainly located in the subcutaneous adipose tissues and appeared to invade the skin. The tumor phenotypes were positive for CAM 5.2, synaptophysin, estrogen receptor, progesterone receptor, and GATA-binding protein 3; they were negative for human epidermal growth receptor 2. The neuroendocrine component comprised more than 90% of the tumor, and the Ki-67 index was 21%. These results indicated that the tumor was a BNET. This patient underwent adjuvant chemotherapy, endocrine therapy, and radiotherapy. Conclusions BNET cases in males are rare. The clinical and histological criteria as well as treatment for these rare cases are discussed.
Databáze: Directory of Open Access Journals
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