Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery
| Autor: | Eric M. Gordon, Dinesh V. Patel, Jeffrey W. Jacobs, Mikhail F. Gordeev, Joseph Zhou |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 51, Iss 11 (1997) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| Popis: | A strategic analysis of various issues which pertain to the enablement of combinatorial organic synthesis to produce libraries of non-polymeric organic molecules is given. Methods and examples of the development of solid-phase organic chemistry and its subsequent application to combinatorial library synthesis for drug discovery is illustrated with successful case studies. The synthetic versatility of resin-bound amino-acid-derived imine intermediates to produces, ?-sultams and pyridines is shown. Use of natural products as key components for creation of combinatorial libraries is presented using Rauwolfia alkaloids and the cephalosporin nucleus as examples. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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