High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up

Autor: Carlos Navarrete-León, P. Stephen Patrick, Adam Doherty, Harry Allan, Silvia Cipiccia, Shashidhara Marathe, Kaz Wanelik, Michela Esposito, Charlotte K. Hagen, Alessandro Olivo, Marco Endrizzi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Synchrotron Radiation, Vol 31, Iss 5, Pp 1293-1298 (2024)
Druh dokumentu: article
ISSN: 1600-5775
16005775
DOI: 10.1107/S1600577524005034
Popis: Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into an array of independent circular beamlets that are resolved by a high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, and enables the three-dimensional reconstructions of the refractive index decrement, δ, and the attenuation coefficient, μ. In this work, the angular sensitivity and the spatial resolution of 2DBT images in a synchrotron-based implementation is reported. In its best configuration, angular sensitivities of ∼20 nrad and spatial resolution of at least 6.25 µm in phase-contrast images were obtained. Exemplar application to the three-dimensional imaging of soft tissue samples, including a mouse liver and a decellularized porcine dermis, is also demonstrated.
Databáze: Directory of Open Access Journals
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