Coordination compounds cobalt bis(citrate)stannate - are results of searching new antiinfluenza drugs

Autor:	M. V. Matyushkina, V. V. Godovan, I. I. Seyfullina, T. L. Grydina
Jazyk:	ruština
Rok vydání:	2014
Předmět:	координационное соединение олово кобальт лимонная кислота вирус гриппа coordination compound tin cobalt citric acid virus of influenza Pharmacy and materia medica RS1-441
Zdroj:	Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 52-56 (2014)
Druh dokumentu:	article
ISSN:	2587-7836 2686-8830
Popis:	The pharmacological properties of new coordination compound - the biologically active substance - cobalt bis(citrate) stannate was studied. The result of researching are: the compound has antiviral activity against human influenza virus strains A/ Honghong/1/68 (H3N2), A/PR/8/34 (H1N1), and influenza virus H5N3 in tissue culture chorio-allantoic membranes (CAM) of chick embryos 11-12 daily and monolayer culture of MDCK cells used. Compound has a low toxicity (by intraperitoneal injection LD50 = 206,63 mg/kg; orally - LD50 = 1836,76), that gives perspective to further his preclinical studies as an antiviral agent.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bfe970badf044d188427b5e2be90c14c Zobrazit plný text záznamu View record in DOAJ