Glucocorticoids and nervous system plasticity

Autor: Kathryn M Madalena, Jessica K Lerch
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Neural Regeneration Research, Vol 11, Iss 1, Pp 37-41 (2016)
Druh dokumentu: article
ISSN: 1673-5374
DOI: 10.4103/1673-5374.175039
Popis: Glucocorticoid and glucocorticoid receptor (GC/GR) interactions alter numerous aspects of neuronal function. These consequences (e.g., anti-inflammatory vs. pro-inflammatory) can vary depending on the duration of GC exposure or central nervous system (CNS) injury model. In this review we discuss how GC/GR interactions impact neuronal recovery after a central or peripheral nerve injury and discuss how GC exposure duration can produce divergent CNS neuronal growth responses. Finally we consider how new findings on gender specific immune cell responses after a nerve injury could intersect with GC/GR interactions to impact pain processing.
Databáze: Directory of Open Access Journals