Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease

Autor:	Andréa M Macedo, Carlos R Machado, Riva P Oliveira, Sérgio DJ Pena
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	Trypanosoma cruzi genetic variability mismatch repair population structure pathogenesis Chagas disease Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 1, Pp 1-12 (2004)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02762004000100001
Popis:	Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cbfe484e58c54a89af8a6876e1d05468 Zobrazit plný text záznamu View record in DOAJ