M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

Autor: Indira Bag, Shue Chen, Leah F. Rosin, Yang Chen, Chen-Yu Liu, Guo-Yun Yu, Elissa P. Lei
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-24407-y
Popis: Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to promote insulator function and activate Motif 1-dependent transcription at topologically associating domain (TAD) borders.
Databáze: Directory of Open Access Journals