Lipid droplets in granulosa cells are correlated with reduced pregnancy rates

Autor:	Shira Raviv, Shay Hantisteanu, Shilhav Meisel Sharon, Yuval Atzmon, Mediea Michaeli, Einat Shalom-Paz
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	BMI Cumulus cells Granulosa cells Lipid droplets CRP leve Gynecology and obstetrics RG1-991
Zdroj:	Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	1757-2215 20266448
DOI:	10.1186/s13048-019-0606-1
Popis:	Abstract Background Lipids are an important source for energy production during oocyte maturation. The accumulation of intracellular lipids binds to proteins to form lipid droplets. This may lead to cellular lipotoxicity. The impact of lipotoxicity on cumulus and granulosa cells has been reported. This pilot study evaluated their correlation to oocyte and embryo quality. Design Prospective case-control study. Setting: Referral IVF unit. Patients: Women younger than age 40, undergoing IVF with intracytoplasmic sperm injection. Interventions: 15 women with BMI > 30 (high BMI) and 26 women with BMI
Databáze:	Directory of Open Access Journals
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