Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.

Autor: Shilpa Pathak, William C L Stewart, Christin E Burd, Mark E Hester, David A Greenberg
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS ONE, Vol 15, Iss 6, p e0234910 (2020)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0234910
Popis: Aging in mammals is the gradual decline of an organism's physical, mental, and physiological capacity. Aging leads to increased risk for disease and eventually to death. Here, we show that Brd2 haploinsufficiency (Brd2+/-) extends lifespan and increases healthspan in C57B6/J mice. In Brd2+/- mice, longevity is increased by 23% (p
Databáze: Directory of Open Access Journals
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