MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling

Autor: Simo Xia, Yijie Tao, Likun Cui, Yizhi Yu, Sheng Xu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Immunology Research, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2314-8861
2314-7156
DOI: 10.1155/2019/5370706
Popis: MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. However, its role in innate antiviral immunity remains unknown. In this study, we found a reduced viral load in MHC I-deficient macrophages that was independent of type I IFN production. Mechanically, MHC I mediated viral suppression by inhibiting the type I IFN signaling pathway, which depends on SHP2. Cross-linking MHC I at the membrane increased SHP2 activation and further suppressed STAT1 phosphorylation. Therefore, our data revealed an inhibitory role of MHC I in type I IFN response to viral infection and expanded our understanding of MHC I and antigen presentation.
Databáze: Directory of Open Access Journals
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