Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis

Autor: Rachana R. Chandran, Yi Xie, Eunate Gallardo-Vara, Taylor Adams, Rolando Garcia-Milian, Inamul Kabir, Abdul Q. Sheikh, Naftali Kaminski, Kathleen A. Martin, Erica L. Herzog, Daniel M. Greif
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27499-8
Popis: The pluripotency factor KLF4 has been described as pro-fibrotic or anti-fibrotic in various diseases. Herein, the authors show that during lung fibrosis, these distinct effects can be attributed to mesenchymal cell-type specific functions of KLF4.
Databáze: Directory of Open Access Journals