68Ga-Prostate-specific membrane antigen (PSMA) positron emission tomography (pet) in prostate cancer: a systematic review and meta-analysis

Autor: Cristina S. Matushita, Ana M. Marques da Silva, Phelipi N. Schuck, Matteo Bardisserotto, Diego B. Piant, Jonatas L. Pereira, Juliano J. Cerci, George B. Coura Filho, Fabio P. Esteves, Barbara J. Amorim, Gustavo V. Gomes, Ana Emília T. Brito, Wanderley M. Bernardo, Eduardo Mundstock, Stefano Fanti, Bruna Macedo, Diego H. Roman, Cinthia Scatolin Tem-Pass, Bruno Hochhegger
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: International Brazilian Journal of Urology, Vol 47, Iss 4, Pp 705-729 (2021)
Druh dokumentu: article
ISSN: 1677-6119
1677-5538
DOI: 10.1590/s1677-5538.ibju.2019.0817
Popis: ABSTRACT Introduction: Prostate cancer (PC) is the second most commonly diagnosed cancer in males. 68Ga-PSMA PET/CT, a non-invasive diagnostic tool to evaluate PC with prostate-specific membrane antigen (PSMA) expression, has emerged as a more accurate alternative to assess disease staging. We aimed to identify predictors of positive 68Ga-PSMA PET and the accuracy of this technique. Materials and methods: Diagnostic accuracy cross-sectional study with prospective and retrospective approaches. We performed a comprehensive literature search on PubMed, Cochrane Library, and Embase database in search of studies including PC patients submitted to radical prostatectomy or radiotherapy with curative intent and presented biochemical recurrence following ASTRO 1996 criteria. A total of 35 studies involving 3910 patients submitted to 68-Ga-PSMA PET were included and independently assessed by two authors: 8 studies on diagnosis, four on staging, and 23 studies on restaging purposes. The significance level was α=0.05. Results: pooled sensitivity and specificity were 0.90 (0.86-0.93) and 0.90 (0.82-0.96), respectively, for diagnostic purposes; as for staging, pooled sensitivity and specificity were 0.93 (0.86-0.98) and 0.96 (0.92-0.99), respectively. In the restaging scenario, pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.45 (0.27-0.58), respectively, considering the identification of prostate cancer in each described situation. We also obtained specificity and sensitivity results for PSA subdivisions. Conclusion: 68Ga-PSMA PET provides higher sensitivity and specificity than traditional imaging for prostate cancer.
Databáze: Directory of Open Access Journals
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