| Autor: |
Mahmoud Abudayyak, Tuğçe Boran, Rumeysa Tukel, Ezgi Oztas, Gül Özhan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Global Medical Genetics, Vol 07, Iss 02, Pp 041-046 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2699-9404 |
| DOI: |
10.1055/s-0040-1715568 |
| Popis: |
Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold interindividual variation among the same genotype. PON1 genotypes were evaluated with the development of pancreatitis, colorectal cancer, and hypothyroidism in a hospital-based, case-control study. Individuals with rs662 G allele had a two-fold risk of developing hypothyroidism. A weak association was found between rs854560 T allele and pancreatitis. The results were preliminary. Further studies with a larger number and detailed biochemical parameters are needed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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