Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

Autor:	Vivek Verma, Simone Bordignon, Michele R. Chierotti, Monica Lestari, Kieran Lyons, Luis Padrela, Kevin M. Ryan, Matteo Lusi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	solid solutions mixed crystals multidrug formulations steroids pharmaceutical solids assisted spray drying hydrogen bonding hydrocortisone cortisone Crystallography QD901-999
Zdroj:	IUCrJ, Vol 7, Iss 6, Pp 1124-1130 (2020)
Druh dokumentu:	article
ISSN:	2052-2525 20522525
DOI:	10.1107/S2052252520013263
Popis:	Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO2 assisted spray drying. In particular, to enter the solid solution, hydrocortisone must violate Etter's rules for hydrogen bonding. As a result, its dissolution rate is almost doubled.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ecbf8e7fceab46978d920b4198abe11f Zobrazit plný text záznamu View record in DOAJ