Potential utilization of neopterin measurements in the assessment of pyrexia in metastatic melanoma treated with combined targeted therapy: a case report

Autor: Bartoušková Marie, Hrouzková Michaela, Čtvrtlík Filip, Petrová Pavla, Rušarová Nikol, Kučerová Kateřina, Vernerová Andrea, Melichar Bohuslav, Študentová Hana
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Pteridines, Vol 31, Iss 1, Pp 151-157 (2020)
Druh dokumentu: article
ISSN: 0933-4807
2195-4720
DOI: 10.1515/pteridines-2020-0009
Popis: In patients with metastatic melanoma the advent of targeted therapy and immune checkpoint inhibitors has transformed the management of advanced and metastatic disease, resulting in improved outcomes. Neopterin is a biomarker of immune activation increased in cancer as well as in other conditions associated with immune activation. We present a case of a patient with advanced metastatic melanoma responding to the combination targeted therapy with dabrafenib and trametinib. The treatment was complicated by a fever that was accompanied by a marked rise in serum and urinary neopterin concentrations. Present case report illustrates not only the efficacy of combined targeted therapy, but also the utilization of neopterin measurements in the diagnosis and monitoring of pyrexia in patients with metastatic malignant melanoma.
Databáze: Directory of Open Access Journals