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Jin Xia,1 Lan Lu,2 Ke-Lei Zhao,2 Qiang-Lin Zeng1 1Department of Respiratory and Critical Care Medicine, Affiliated Hospital/Clinical College of Chengdu University, Chengdu, Sichuan, 610081, People’s Republic of China; 2Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, Sichuan, 610106, People’s Republic of ChinaCorrespondence: Ke-Lei Zhao, Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, Sichuan, 610106, People’s Republic of China, Tel +86 173 401 901 21, Email zhaokelei@cdu.edu.cn Qiang-Lin Zeng, Department of Respiratory and Critical Care Medicine, Affiliated Hospital/Clinical college of Chengdu University, Chengdu, Sichuan, 610081, People’s Republic of China, Email zengqianglin@cdu.edu.cnObjective: To investigate the impact of coronavirus disease 2019 (COVID-19) specified preventive and control measures on the distribution and resistance transition of Pseudomonas aeruginosa (P. aeruginosa) in uninfected hospitalized patients during the pandemic.Methods: This retrospective study retrieved data from 316 P. aeruginosa isolates in the year pre-COVID-19 (n=131) pandemic and the year under COVID-19 specified preventive and control (post-pandemic year, n=185), compared the general characteristics, laboratory results, and antimicrobial susceptibility tests of P. aeruginosa between the two groups.Results: Compared with the pre-pandemic year, the isolation rate of P. aeruginosa (14.35% vs 22.31%, P< 0.001) increased, while the rate of drug resistant P. aeruginosa decreased significantly (29.77% vs 19.45%, P< 0.001) in the post-pandemic year; Prescription of β-Lactams (30.5% vs 50.0%, P< 0.01) also increased significantly. The resistance rates of P. aeruginosa isolates to ceftazidime (P< 0.01), ciprofloxacin (P< 0.01), and gentamicin (P< 0.001) increased, whereas the resistance rates to piperacillin/tazobactam (P< 0.01) and imipenem (P< 0.05) decreased significantly.Conclusion: The COVID-19 specified preventive and control measures have influenced the distribution and resistance transition of P. aeruginosa, further verifications are needed in future research.Keywords: COVID-19, Pseudomonas aeruginosa, isolation rate, drug resistance |
