| Autor: |
Roberta Marzi, Jessica Bassi, Chiara Silacci-Fregni, Istvan Bartha, Francesco Muoio, Katja Culap, Nicole Sprugasci, Gloria Lombardo, Christian Saliba, Elisabetta Cameroni, Antonino Cassotta, Jun Siong Low, Alexandra C. Walls, Matthew McCallum, M. Alejandra Tortorici, John E. Bowen, Exequiel A. Dellota, Jr., Josh R. Dillen, Nadine Czudnochowski, Laura Pertusini, Tatiana Terrot, Valentino Lepori, Maciej Tarkowski, Agostino Riva, Maira Biggiogero, Alessandra Franzetti-Pellanda, Christian Garzoni, Paolo Ferrari, Alessandro Ceschi, Olivier Giannini, Colin Havenar-Daughton, Amalio Telenti, Ann Arvin, Herbert W. Virgin, Federica Sallusto, David Veesler, Antonio Lanzavecchia, Davide Corti, Luca Piccoli |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
iScience, Vol 26, Iss 1, Pp 105726- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.105726 |
| Popis: |
Summary: Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with a pathogen. Here, we investigated the kinetics, avidity, and cross-reactivity of serum antibodies and MBCs in 155 SARS-CoV-2 infected and vaccinated individuals over a 16-month time frame. SARS-CoV-2-specific MBCs and serum antibodies reached steady-state titers with comparable kinetics in infected and vaccinated individuals. Whereas MBCs of infected individuals targeted both prefusion and postfusion Spike (S), most vaccine-elicited MBCs were specific for prefusion S, consistent with the use of prefusion-stabilized S in mRNA vaccines. Furthermore, a large fraction of MBCs recognizing postfusion S cross-reacted with human betacoronaviruses. The avidity of MBC-derived and serum antibodies increased over time resulting in enhanced resilience to viral escape by SARS-CoV-2 variants, including Omicron BA.1 and BA.2 sublineages, albeit only partially for BA.4 and BA.5 sublineages. Overall, the maturation of high-affinity and broadly reactive MBCs provides the basis for effective recall responses to future SARS-CoV-2 variants. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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