Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas.
| Autor: | Diana L Fabbro, Emmaria Danesi, Veronica Olivera, Maria Olenka Codebó, Susana Denner, Cecilia Heredia, Mirtha Streiger, Sergio Sosa-Estani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 8, Iss 11, p e3312 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1935-2727 1935-2735 |
| DOI: | 10.1371/journal.pntd.0003312 |
| Popis: | With the control of the vectorial and transfusional routes of infection with Trypanosoma cruzi, congenital transmission has become an important source of new cases. This study evaluated the efficacy of trypanocidal therapy to prevent congenital Chagas disease and compared the clinical and serological evolution between treated and untreated infected mothers. We conducted a multicenter, observational study on a cohort of mothers infected with T. cruzi, with and without trypanocidal treatment before pregnancy. Their children were studied to detect congenital infection. Among 354 "chronically infected mother-biological child" pairs, 132 were treated women and 222 were untreated women. Among the children born to untreated women, we detected 34 infected with T. cruzi (15.3%), whose only antecedent was maternal infection. Among the 132 children of previously treated women, no infection with T. cruzi was found (0.0%) (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|