2-Hydroxyoleic acid-inserted liposomes as a multifunctional carrier of anticancer drugs

Autor:	Eun-Ji Jang, Woo Rim Choi, Soo-Yeon Kim, Soon-Seok Hong, Inmoo Rhee, Sang-Jin Lee, Sung Weon Choi, Han-Gon Choi, Soo-Jeong Lim
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	2-hydroxyoleic acid liposome multifunctional carrier hydrophobic drug Therapeutics. Pharmacology RM1-950
Zdroj:	Drug Delivery, Vol 24, Iss 1, Pp 1587-1597 (2017)
Druh dokumentu:	article
ISSN:	1071-7544 1521-0464 10717544
DOI:	10.1080/10717544.2017.1388452
Popis:	Studies have shown that insertion of oleic acid into lipid bilayers can modulate the membrane properties of liposomes so as to improve their function as drug carriers. Considering that 2-hydroxyoleic acid (2OHOA), a potential antitumor agent currently undergoing clinical trials, is a derivative of oleic acid, we explored the possibility of developing 2OHOA-inserted liposomes as a multifunctional carrier of antitumor drugs in the present study. The insertion of 2OHOA into lipid bilayers was confirmed by surface charge determination and differential scanning calorimetry. 2OHOA insertion greatly decreased the order of dimyristoylphosphatidylcholine packing, produced a nanosized (
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bf71de5448cc4a3f89aa82536dac3e7b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.