Evaluation of circulating CD4CD25CD127 regulatory T cells in newly diagnosed hepatitis C-infected patients

Autor: Morvarid Asadipour, Soolmaz Khansalar, Fatemeh Rezaei Kahmini, Mahsa Eshkevar Vakili, Mohammad Reza Ataollahi, Mohammad Ali-Hassanzadeh, Keivan Shams, Zahra Faghih, Kurosh Kalantar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: European Journal of Inflammation, Vol 22 (2024)
Druh dokumentu: article
ISSN: 2058-7392
1721727X
DOI: 10.1177/1721727X241242701
Popis: Objectives Hepatitis C virus (HCV) is one of the most global health problems with 2.5% prevalence worldwide. It seems that regulatory T (Treg) cells, which are able to modulate the host immune responses, play a substantial role in the immunopathogenesis of HCV infection. In this study, we evaluated the distribution of Treg cells in HCV-infected patients and its correlation with viral load and clinical manifestations. Methods Peripheral blood mononuclear cells (PBMCs) were collected from 14 newly diagnosed HCV-infected patients and 23 age- and sex-matched healthy subjects, and the frequency of CD4+CD25+CD127−/low Treg cells was determined by flow cytometry. Results Our results showed that the mean level of CD4+CD25+CD127−/low Treg cells in HCV-infected patients was significantly higher than that in healthy control subjects (8.2 ± 1.48% vs 5.4 ± 0.36%, p < .05). However, there was no statistical correlation between Treg cells frequency and viral load or clinical manifestations. Conclusion A higher proportion of Treg cells in HCV-infected patients might indicate their critical role in viral persistence and candidate them as a new target of immunotherapy to improve antiviral immunity.
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