Safety and protective effect of Cenchrus echinatus on breast cancer induced in rats
| Autor: | César B. Cisneros Hilario, Jorge L. Arroyo Acevedo, María P. Bedoya Castillo, Betsy A. Lázaro Huamán, Katia E. Mendoza Chávez, Evelin J. Cisneros Hilario |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Revista de la Facultad de Medicina Humana, Vol 22, Iss 3, Pp 452-462 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1814-5469 2308-0531 |
| DOI: | 10.25176/RFMH.v22i3.4915 |
| Popis: | Introduction: Breast cancer is a disease that is increasing its incidence annually, so in search of complementary alternatives for treatment have been studied some medicinal plants containing large amounts of polyphenols, which have anticancer effects as is the case of Cenchrus echinatus L. Objective: To determine the safety and protective effect of ethanol extract of Cenchrus echinatus L. (burdock) on breast cancer induced by 7,12-dimethylbenz[a]anthracene in rats. Methods: Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity and toxicity at 45 days were calculated using probit and OECD methods, respectively; to evaluate the protective effect, the Barros 2004 method was used; tumor cell proliferation was also registered microscopically, using descriptive and inferential statistical analysis, considering p |
| Databáze: | Directory of Open Access Journals |
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