Inflammation: A Target for Treatment in Spinal Cord Injury

Autor: Ximena Freyermuth-Trujillo, Julia J. Segura-Uribe, Hermelinda Salgado-Ceballos, Carlos E. Orozco-Barrios, Angélica Coyoy-Salgado
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Cells, Vol 11, Iss 17, p 2692 (2022)
Druh dokumentu: article
ISSN: 2073-4409
DOI: 10.3390/cells11172692
Popis: Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that generate beneficial outcomes and have no side effects are urgently needed. SCI may be treatable if intervention is initiated promptly. Therefore, several treatment proposals are currently being evaluated. Inflammation is part of a complex physiological response to injury or harmful stimuli induced by mechanical, chemical, or immunological agents. Neuroinflammation is one of the principal secondary changes following SCI and plays a crucial role in modulating the pathological progression of acute and chronic SCI. This review describes the main inflammatory events occurring after SCI and discusses recently proposed potential treatments and therapeutic agents that regulate inflammation after insult in animal models.
Databáze: Directory of Open Access Journals
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