| Autor: |
Francisco Albuquerque, Afonso Félix Oliveira, Pedro de Araújo Gonçalves, Rui Campante Teles, Manuel de Sousa Almeida, Mariana Gonçalves, Pedro M. Lopes, Gonçalo J.L. Cunha, João Presume, Daniel Matos, Sérgio Madeira, João Brito, Luís Raposo, Henrique Mesquita Gabriel, Miguel Mendes |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Revista Portuguesa de Cardiologia, Vol 42, Iss 1, Pp 21-28 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0870-2551 |
| DOI: |
10.1016/j.repc.2021.09.020 |
| Popis: |
Introduction and Objectives: Obstructive coronary artery disease (CAD) remains the most common etiology of heart failure with reduced ejection fraction (HFrEF). However, there is controversy whether invasive coronary angiography (ICA) should be used initially to exclude CAD in patients presenting with new-onset HFrEF of unknown etiology. Our study aimed to develop a clinical score to quantify the risk of obstructive CAD in these patients. Methods: We performed a cross-sectional observational study of 452 consecutive patients presenting with new-onset HFrEF of unknown etiology undergoing elective ICA in one academic center, between January 2005 and December 2019. Independent predictors for obstructive CAD were identified. A risk score was developed using multivariate logistic regression of designated variables. The accuracy and discriminative power of the predictive model were assessed. Results: A total of 109 patients (24.1%) presented obstructive CAD. Six independent predictors were identified and included in the score: male gender (2 points), diabetes (1 point), dyslipidemia (1 point), smoking (1 point), peripheral arterial disease (1 point), and regional wall motion abnormalities (3 points). Patients with a score ≤3 had less than 15% predicted probability of obstructive CAD. Our score showed good discriminative power (C-statistic 0.872; 95% CI 0.834–0.909: p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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