Prognostic Implications of Coronary Artery Sclerosis in Troponin-Positive Patients with Non-Obstructive Coronary Arteries

Autor: Fabienne Kreimer, Clara Schlettert, Mohammad Abumayyaleh, Ibrahim Akin, Daniel Materzok, Michael Gotzmann, Fabian Schiedat, Harilaos Bogossian, Mido Max Hijazi, Nazha Hamdani, Andreas Mügge, Ibrahim El-Battrawy, Rayyan Hemetsberger, Assem Aweimer
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiology and Therapy, Vol 13, Iss 3, Pp 557-574 (2024)
Druh dokumentu: article
ISSN: 2193-8261
2193-6544
DOI: 10.1007/s40119-024-00375-4
Popis: Abstract Introduction Coronary sclerosis is a risk factor for the progression to obstructive coronary artery disease (CAD). However, understanding its impact on the outcomes of patients with myocardial infarction and non-obstructive coronary arteries is limited. This study aimed to explore the prognostic influence of coronary sclerosis on in- and out-of-hospital events in troponin-positive patients with non-obstructive coronary arteries. Methods This study was a retrospective cohort analysis based on prospectively collected data. A total of 24,775 patients who underwent coronary angiography from 2010 to 2021 in a German university hospital were screened, resulting in a final study cohort of 373 troponin-positive patients with non-obstructive coronary arteries and a follow-up period of 6.2 ± 3.1 years. Coronary sclerosis was defined as coronary plaques without angiographically detectable stenotic lesions of 50% or more in the large epicardial coronary arteries. The primary study endpoint was the occurrence of in-hospital events. Secondary endpoints included events during follow-up. Results Patients with coronary sclerosis were significantly older (70 ± 12 vs. 58 ± 16 years, p
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