Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia

Autor:	Cécile Thirant, Cécile Lopez, Sébastien Malinge, Thomas Mercher
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	amkl enhancer erg eto2 gata glis2 leukemia nc128 transcription factor Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2017.1345351
Popis:	The ETO2-GLIS2 fusion oncoprotein is associated with poor prognosis pediatric acute megakaryoblastic leukemia. Recently, we observed that ETO2-GLIS2 controls enhancers activity at genes regulating haematopoietic progenitor self-renewal and differentiation toward the megakaryocytic lineage. We also showed that targeting ETO2-GLIS2 complex stability inhibits these properties and may represent a novel therapeutic strategy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bf374fec8390479c838deeee62c2d1d0 Zobrazit plný text záznamu View record in DOAJ