Tryptophanyl tRNA synthetase is an alternative synovial biomarker for diagnosis of septic arthritis in knee joint

Autor: Byung Hoon Lee, Young Gon Na, Seong Hyup Ham, Mirim Jin, Yoon Tae Kim, Kyung-Ok Kim, Jae Ang Sim
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Knee Surgery & Related Research, Vol 36, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 2234-2451
DOI: 10.1186/s43019-024-00229-2
Popis: Abstract Background To evaluate the diagnostic characteristics of tryptophanyl tRNA synthetase (WRS) for the diagnosis of septic arthritis of the knee joint and to determine whether it is a reliable and sensitive synovial biomarker for discriminating septic arthritis from other types of arthritis. Methods Patients joint effusions for which septic arthritis was suspected were prospectively recruited between January 2019 and September 2020. A total of 9 patients had septic arthritis, 6 had acute gout attack, 1 had an acute flare of chronic rheumatic arthritis, and 46 had pseudogout or reactive arthropathy. Traditional inflammatory markers were measured, and their diagnostic abilities were compared. Neutrophil count, C-reactive protein (CRP) level, WRS, and human neutrophil α-defensin levels were assessed in the synovial fluids. Demographic parameters and biomarkers with a P
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