| Autor: |
Joan Gannon, Julia Fernandez-Rodriguez, Hussam Alamri, Shi Bo Feng, Fariba Kalantari, Sarita Negi, Amy H Y Wong, Alexander Mazur, Lennart Asp, Ali Fazel, Ayat Salman, Anthoula Lazaris, Peter Metrakos, John J M Bergeron, Tommy Nilsson |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 11, p e111309 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0111309 |
| Popis: |
The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of both COPI and clathrin-coated vesicles. In this study, we show that ARFGAP1 associates transiently with lipid droplets upon addition of oleate in cultured cells. Also, that addition of cyclic AMP shifts ARFGAP1 from lipid droplets to the Golgi apparatus and that overexpression and knockdown of ARFGAP1 affect lipid droplet formation. Examination of human liver tissue reveals that ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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