| Autor: |
Valsamma Eapen, Rudi Črnčec, Anna Xenia Pick, Owen Tsao, Richard Lai, Janette Lee, Paul F. Sowman |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Integrative Neuroscience, Vol 21, Iss 3, p 89 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
0219-6352 |
| DOI: |
10.31083/j.jin2103089 |
| Popis: |
Background: Gilles de la Tourette Syndrome (GTS) is a childhood-onset neuropsychiatric disorder characterised by motor and vocal tics. While Comprehensive Behavioural Intervention for Tics (CBIT) is an effective, non-pharmacological treatment for patients with GTS, the underlying neurophysiological basis of this intervention has not been investigated. Methods: To investigate the clinical effectiveness of CBIT in reducing tic severity in young people with GTS and explore neurophysiological mechanisms associated with clinical change. Results: There was a significant overall improvement in tic severity of large effect size. The Cortical Silent Period (CSP) to motor evoked potential (MEP) ratio (CSP/MEP ratio) increased after the intervention with a small effect size. Other neurophysiological measures of inhibition were not significantly related to the change in tic severity. Conclusions: Alongside significant clinical improvements, these results suggest a role for motor cortical Gamma-aminobutyric acid (GABA)-ergic inhibitory circuitry in the neurophysiological changes underlying CBIT treatment. These findings need to be replicated in larger studies using control samples. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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